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Dipeptidase 1, Renal (DPEP1)

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RDP; MBD1; MDP; Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase

Dipeptidase 1, Renal (DPEP1)
CCC C441
HGNC 3002
MGI 94917
PubMed 22363658
RGD 620324
UniProt P16444
Wiki Dipeptidase_1

DPEP1 (EC 3.4.13.11) is a kidney membrane enzyme that hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates, e.g., leukotriene D4 (Kozak and Tate, 1982).

DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics, such as penem and carbapenem (Campbell et al., 1984). Earlier, beta-lactamase enzymes were thought to occur only in bacteria, where their probable function was in protecting the organisms against the action of beta-lactam antibiotics. These antibiotics exhibit selective toxicity against bacteria but virtual inertness against many eukaryotic cells (Adachi et al., 1990).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC441Hu01 Recombinant Dipeptidase 1, Renal (DPEP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC441Hu01 Polyclonal Antibody to Dipeptidase 1, Renal (DPEP1) WB
MAC441Hu21 Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) WB
MAC441Hu22 Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) WB
Assay Kits SEC441Hu ELISA Kit for Dipeptidase 1, Renal (DPEP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dipeptidase 1, Renal (DPEP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dipeptidase 1, Renal (DPEP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dipeptidase 1, Renal (DPEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dipeptidase 1, Renal (DPEP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dipeptidase 1, Renal (DPEP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dipeptidase 1, Renal (DPEP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dipeptidase 1, Renal (DPEP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dipeptidase 1, Renal (DPEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dipeptidase 1, Renal (DPEP1) ELISA Kit Customized Service Offer
  1. "Cloning and structural analysis of genomic DNA for human renal dipeptidase."Biochim. Biophys. Acta 1172:181-183(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure of human microsomal dipeptidase deduced from molecular cloning."J. Biol. Chem. 265:3992-3995(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Gene structural analysis and expression of human renal dipeptidase."Biotechnol. Prog. 10:134-140(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme."Biochem. J. 265:429-433(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and characterization of human microsomal dipeptidase."J. Biochem. 105:957-961(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of membrane anchoring site of human renal dipeptidase and construction and expression of a cDNA for its secretory form."J. Biol. Chem. 265:15341-15345(1990) [PubMed] [Europe PMC] [Abstract]
  9. "Importance of Glu-125 in the catalytic activity of human renal dipeptidase."Biochim. Biophys. Acta 1163:42-48(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis."J. Mol. Biol. 321:177-184(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]