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Eukaryotic Translation Initiation Factor 2C4 (EIF2C4)

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AGO4; Argonaute 4; Argonaute RISC catalytic component 4

Eukaryotic Translation Initiation Factor 2C4 (EIF2C4)
CCC E990
HGNC 18424
MGI 1924100
PubMed 20146808
RGD 1304583
UniProt Q9HCK5
EIF2C4 encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1.
The deduced 924-amino acid protein shares 80% identity with rabbit translation initiation factor Eif2c. RT-PCR followed by ELISA revealed intermediate and nearly uniform levels of expression in all tissues and specific brain regions tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE990Hu01 Recombinant Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE990Ra01 Recombinant Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 2C4 (EIF2C4) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs."Mol. Cell 15:185-197(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis."RNA 10:1518-1525(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Inhibition of translational initiation by Let-7 MicroRNA in human cells."Science 309:1573-1576(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Importance of translation and nonnucleolytic ago proteins for on-target RNA interference."Curr. Biol. 18:1327-1332(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Capped small RNAs and MOV10 in human hepatitis delta virus replication."Nat. Struct. Mol. Biol. 15:714-721(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs."Cell 136:496-507(2009) [PubMed] [Europe PMC] [Abstract]