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Carboxylesterase 3 (CES3)

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Br3; ES31; Brain carboxylesterase 3; Esterase 31; Liver carboxylesterase 31 homolog

Carboxylesterase 3 (CES3)
CCC F283
HGNC 1865
MGI 2148202
PubMed 20197051
RGD 70896
UniProt Q6UWW8
Wiki CES3
Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood-brain barrier system. The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. In addition, please note that the human CES3 gene is not orthologous to the mouse Ces3 gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF283Hu01 Recombinant Carboxylesterase 3 (CES3) Positive Control; Immunogen; SDS-PAGE; WB.
APF283Hu01 Active Carboxylesterase 3 (CES3) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Carboxylesterase 3 (CES3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxylesterase 3 (CES3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxylesterase 3 (CES3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxylesterase 3 (CES3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF283Mu01 Recombinant Carboxylesterase 3 (CES3) Positive Control; Immunogen; SDS-PAGE; WB.
APF283Mu01 Active Carboxylesterase 3 (CES3) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Carboxylesterase 3 (CES3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxylesterase 3 (CES3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxylesterase 3 (CES3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxylesterase 3 (CES3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF283Ra01 Recombinant Carboxylesterase 3 (CES3) Positive Control; Immunogen; SDS-PAGE; WB.
APF283Ra01 Active Carboxylesterase 3 (CES3) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Carboxylesterase 3 (CES3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxylesterase 3 (CES3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxylesterase 3 (CES3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxylesterase 3 (CES3) ELISA Kit Customized Service Offer
  1. "Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3."Drug Metab. Dispos. 32:505-511(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis."Clin. Cancer Res. 9:4983-4991(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide."J. Pharmacol. Exp. Ther. 313:1011-1016(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]