Carboxypeptidase N1 (CPN1)

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CPN; SCPN; ACBP; Anaphylatoxin inactivator; Arginine carboxypeptidase; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N

Carboxypeptidase N1 (CPN1)
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator.
This enzyme is a tetramer composed of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.The predicted protein is 458 amino acids long. Carboxypeptidase N is a 280-kD tetrameric complex consisting of 2 identical 83-kD regulatory subunits and 2 identical 50-kD catalytic subunits.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF323Hu01 Recombinant Carboxypeptidase N1 (CPN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPF323Hu02 Recombinant Carboxypeptidase N1 (CPN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF323Hu01 Polyclonal Antibody to Carboxypeptidase N1 (CPN1) WB
PAF323Hu02 Polyclonal Antibody to Carboxypeptidase N1 (CPN1) WB; IHC; ICC; IP.
LAF323Hu71 Biotin-Linked Polyclonal Antibody to Carboxypeptidase N1 (CPN1) WB; IHC; ICC.
Assay Kits SEF323Hu ELISA Kit for Carboxypeptidase N1 (CPN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF323Mu01 Recombinant Carboxypeptidase N1 (CPN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPF323Mu02 Recombinant Carboxypeptidase N1 (CPN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF323Mu01 Polyclonal Antibody to Carboxypeptidase N1 (CPN1) WB; IHC; ICC; IP.
PAF323Mu02 Polyclonal Antibody to Carboxypeptidase N1 (CPN1) WB; IHC; ICC; IP.
Assay Kits SEF323Mu ELISA Kit for Carboxypeptidase N1 (CPN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carboxypeptidase N1 (CPN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carboxypeptidase N1 (CPN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carboxypeptidase N1 (CPN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carboxypeptidase N1 (CPN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carboxypeptidase N1 (CPN1) ELISA Kit Customized Service Offer
  1. "cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1)."Eur. J. Biochem. 178:603-607(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases."Biochem. Biophys. Res. Commun. 154:1323-1329(1988) [PubMed] [Europe PMC] [Abstract]
  5. "On the specificity of carboxypeptidase N, a comparative study."Biol. Chem. Hoppe-Seyler 374:843-849(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain."J. Mol. Biol. 366:504-516(2007) [PubMed] [Europe PMC] [Abstract]
  7. "DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency."J. Hum. Genet. 48:20-22(2003) [PubMed] [Europe PMC] [Abstract]