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Cellular Retinoic Acid Binding Protein 2 (CRABP2)

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CRABP-II; RBP6

Cellular Retinoic Acid Binding Protein 2 (CRABP2)
CCC F331
HGNC 2339
MGI 88491
PubMed 23383201
RGD 62070
UniProt P29373
Wiki CRABP2
The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein.It was shown to be approximately 4.6 kb long and divided into 4 exons in a structure common to other members of the family of serum and cellular retinoid-binding proteins. The chromosomal location of the Crabp-2 locus was determined by interspecific backcross analysis using progeny derived from matings of C57BL/6J and M. spretus. Mapping results indicated that the gene is located on mouse chromosome 2 linked to muscle nicotinic acetylcholine receptor alpha-chain (Acra) and catalase-1 (Cas-1).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF331Hu01 Recombinant Cellular Retinoic Acid Binding Protein 2 (CRABP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF331Hu01 Polyclonal Antibody to Cellular Retinoic Acid Binding Protein 2 (CRABP2) WB; IHC; FCM
MAF331Hu21 Monoclonal Antibody to Cellular Retinoic Acid Binding Protein 2 (CRABP2) WB
MAF331Hu22 Monoclonal Antibody to Cellular Retinoic Acid Binding Protein 2 (CRABP2) WB
MAF331Hu23 Monoclonal Antibody to Cellular Retinoic Acid Binding Protein 2 (CRABP2) WB; IHC; ICC; IP.
Assay Kits SEF331Hu ELISA Kit for Cellular Retinoic Acid Binding Protein 2 (CRABP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cellular Retinoic Acid Binding Protein 2 (CRABP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cellular Retinoic Acid Binding Protein 2 (CRABP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cellular Retinoic Acid Binding Protein 2 (CRABP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cellular Retinoic Acid Binding Protein 2 (CRABP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cellular Retinoic Acid Binding Protein 2 (CRABP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cellular Retinoic Acid Binding Protein 2 (CRABP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cellular Retinoic Acid Binding Protein 2 (CRABP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cellular Retinoic Acid Binding Protein 2 (CRABP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cellular Retinoic Acid Binding Protein 2 (CRABP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cellular Retinoic Acid Binding Protein 2 (CRABP2) ELISA Kit Customized Service Offer
  1. "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro."J. Biol. Chem. 266:17662-17666(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The molecular cloning and expression of two CRABP cDNAs from human skin."Exp. Cell Res. 198:328-336(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the human cellular retinoic acid-binding protein II gene. Early transcriptional regulation by retinoic acid."J. Biol. Chem. 267:25251-25255(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest."Mol. Cell. Biol. 22:2632-2641(2002) [PubMed] [Europe PMC] [Abstract]
  9. "A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II."Mol. Cell 18:343-353(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation."J. Biol. Chem. 286:42749-42757(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid."Structure 2:1241-1258(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of apo-cellular retinoic acid-binding protein type II (R111M) suggests a mechanism of ligand entry."J. Mol. Biol. 278:641-653(1998) [PubMed] [Europe PMC] [Abstract]
  14. "Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids."Acta Crystallogr. D 55:1850-1857(1999) [PubMed] [Europe PMC] [Abstract]
  15. "NMR solution structure of type II human cellular retinoic acid binding protein: implications for ligand binding."Biochemistry 37:12727-12736(1998) [PubMed] [Europe PMC] [Abstract]
  16. "NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein."Biochemistry 37:13021-13032(1998) [PubMed] [Europe PMC] [Abstract]
  17. "The structure of apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation."J. Mol. Biol. 363:687-701(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic."J. Am. Chem. Soc. 129:6140-6148(2007) [PubMed] [Europe PMC] [Abstract]