G Protein Coupled Receptor 142 (GPR142)

GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs).CloningBack to Top By searching databases for sequences similar to rhodopsin-like GPRs, Fredriksson et al. (2003) identified GPR142. The deduced 462-amino acid protein assumes a classic 7-transmembrane (TM) topology and has a DRY motif in the intracellular side of TM3. It also contains a NPxxY motif. GPR142 shares 68% amino acid identity with mouse Gpr142.

Fredriksson et al. (2003) determined that the GPR142 gene contains 4 coding exons. The mouse Gpr142 gene contains 3 coding exons.By genomic sequence analysis, Fredriksson et al. (2003) mapped the GPR142 gene to chromosome 17q25.1. They mapped the mouse Gpr142 gene to chromosome 11.