Zinc Finger Protein 100 (ZNF100)

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. By PCR-based screening of a human genomic YAC library using degenerate oligonucleotides corresponding to a consensus sequence of the spacer region of ZNF91 family members, Bellefroid et al. (1993) identified 23 distinct ZNF91-related genes, including ZNF100. They demonstrated that members of the ZNF91 family are widely expressed in human tissues, with the highest expression in T-lymphoid cells.

Bellefroid et al. (1993) mapped YAC clones containing ZNF91-related genes by FISH and found that most of these genes, including ZNF100, are clustered in 19p13.1-p12.