Defensin Beta 110 (DEFb110)

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DEFB111; DEFB-10; DEFB-11

Defensin Beta 110 (DEFb110)
DEFb110 belongs to the beta-defensin family. The innate immune system includes antimicrobial peptides that protect multicellular organisms from a diverse spectrum of microorganisms. beta-Defensins comprise one important family of mammalian antimicrobial peptides. This strategy identified 28 new human and 43 new mouse beta-defensin genes in five syntenic chromosomal regions. Within each syntenic cluster, the gene sequences and organization were similar, suggesting each cluster pair arose from a common ancestor and was retained because of conserved functions. Preliminary analysis indicates that at least 26 of the predicted genes are transcribed. These results demonstrate the value of a genomewide search strategy to identify genes with conserved structural motifs. Discovery of these genes represents a new starting point for exploring the role of beta-defensins in innate immunity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Defensin Beta 110 (DEFb110) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Defensin Beta 110 (DEFb110) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Defensin Beta 110 (DEFb110) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Defensin Beta 110 (DEFb110) CLIA Kit Customized Service Offer
n/a ELISA Kit for Defensin Beta 110 (DEFb110) ELISA Kit Customized Service Offer
  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]