≡

Salt Inducible Kinase 3 (SIK3)

[Edit]

QSK; Serine/threonine-protein kinase SIK3; Serine/threonine-protein kinase QSK

Salt Inducible Kinase 3 (SIK3)
CCC T750
HGNC 29165
MGI 2446296
PubMed 22318228
UniProt Q9Y2K2
SIK3, Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. Contains 1 protein kinase domain. Contains 1 UBA domain. Activated by phosphorylation on Thr-163 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.
In Drosophila and C. elegans, signal transduction pathways initiated by the activation of receptor-protein tyrosine kinases can mediate developmental fate decisions. One, designated Hek2, encodes the mouse ortholog of human HEK2, a member of the eph receptor protein tyrosine kinase gene family. The other, designated msk (myocardial Snf1-like kinase), encodes a putative protein serine/threonine kinase most similar to the yeast protein Snf1, which is involved in the response to nutritional stress.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Salt Inducible Kinase 3 (SIK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Salt Inducible Kinase 3 (SIK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Salt Inducible Kinase 3 (SIK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Salt Inducible Kinase 3 (SIK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Salt Inducible Kinase 3 (SIK3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Salt Inducible Kinase 3 (SIK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Salt Inducible Kinase 3 (SIK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Salt Inducible Kinase 3 (SIK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Salt Inducible Kinase 3 (SIK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Salt Inducible Kinase 3 (SIK3) ELISA Kit Customized Service Offer
  1. "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."EMBO J. 23:833-843(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
  8. "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK."J. Cell Sci. 118:5661-5673(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]