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Isoprenoid Synthase Domain Containing Protein (ISPD)

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Nip; Notch1-Induced Protein; 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Synthase Homolog; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein

Isoprenoid Synthase Domain Containing Protein (ISPD)
CCC T839
HGNC 37276
MGI 1923097
PubMed 21543842
RGD 1359368
UniProt A4D126
A hypothetical gene with similarity to the gene of Escherichia coli was cloned from Arabidopsis thaliana cDNA. The ORF of 909 bp specifies a protein of 302 amino acid residues. The cognate chromosomal gene consists of 2,071 bp and comprises 11 introns with a size range of 78–202 bp. A fragment comprising amino acid residues 76–302 was expressed in a recombinant E. coli strain.
Numb and Notch signalling pathways are vitally important in cell fate and differentiation. The outcome of these signalling processes is determined by a delicate balance between opposing effects of Notch and Numb. Imbalance in Numb/Notch regulation was implicated in aberrant differentiation programme and epithelial cancer progression and metastasis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Isoprenoid Synthase Domain Containing Protein (ISPD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Isoprenoid Synthase Domain Containing Protein (ISPD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Isoprenoid Synthase Domain Containing Protein (ISPD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Isoprenoid Synthase Domain Containing Protein (ISPD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Isoprenoid Synthase Domain Containing Protein (ISPD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Isoprenoid Synthase Domain Containing Protein (ISPD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Isoprenoid Synthase Domain Containing Protein (ISPD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Isoprenoid Synthase Domain Containing Protein (ISPD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Isoprenoid Synthase Domain Containing Protein (ISPD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Isoprenoid Synthase Domain Containing Protein (ISPD) ELISA Kit Customized Service Offer
  1. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  3. "ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome."Nat. Genet. 44:575-580(2012) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of mutations in TMEM5 and ISPD as a cause of severe cobblestone lissencephaly." Am. J. Hum. Genet. 91:1135-1143(2012) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of alpha-dystroglycan." Nat. Genet. 44:581-585(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Limb-girdle muscular dystrophy with alpha-dystroglycan deficiency and mutations in the ISPD gene."Neurology 80:963-965(2013) [PubMed] [Europe PMC] [Abstract]