Ubiquitin Specific Peptidase 17 Like Protein 5 (USP17L5)

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Deubiquitinating Enzyme 17-Like Protein 5; Ubiquitin Thiolesterase 17-Like Protein 5; Ubiquitin-Specific-Processing Protease 17-Like Protein 5

Ubiquitin Specific Peptidase 17 Like Protein 5 (USP17L5)
USP17L5 belongs to the peptidase C19 family, USP17 subfamily. While identifying putative ubiquitin specific protease (USP) enzymes that contain a conserved Asp (I) domain in humans, 4 USP17 subfamily members, highly homologous to DUB-3, have been found, from human chorionic villi. Expression analysis showed that USP17 transcripts are highly expressed in the heart, liver, and pancreas and are expressed moderately in various human cancerous cell lines. Amino acid sequence analysis revealed that they contain the highly conserved Cys, His, and Asp domains which are responsible for the deubiquitinating activity. Interestingly, the sequence analysis showed that these proteins, with exception of USP17N, contain the putative hyaluronan/RNA binding motifs, and cetylpyridinium chloride (CPC)-precipitation analysis confirmed the association between these proteins and intracellular hyaluronan and RNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 17 Like Protein 5 (USP17L5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 17 Like Protein 5 (USP17L5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 17 Like Protein 5 (USP17L5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 17 Like Protein 5 (USP17L5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 17 Like Protein 5 (USP17L5) ELISA Kit Customized Service Offer
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence."Genomics 85:524-529(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability."BMC Genomics 7:292-292(2006) [PubMed] [Europe PMC] [Abstract]