Monocyte Chemotactic Protein 3 (MCP3)

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CCL7; FIC; MARC; NC28; MCP3; SCYA7; Chemokine C-C-Motif Ligand 7; Small Inducible Cytokine A7; Monocyte Chemoattractant Protein 3

Monocyte Chemotactic Protein 3 (MCP3)

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines.

The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. CCL7 is one of the most pluripotent chemokines, produced by certain tumor cell lines and by macrophages and acting on multiple cell types including monocytes, lymphocytes, eosinophils, basophils, dendritic cells, and natural killer cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA089Hu01 Recombinant Monocyte Chemotactic Protein 3 (MCP3) Positive Control; Immunogen; SDS-PAGE; WB.
APA089Hu01 Active Monocyte Chemotactic Protein 3 (MCP3) Cell culture; Activity Assays.
Antibodies PAA089Hu01 Polyclonal Antibody to Monocyte Chemotactic Protein 3 (MCP3) WB; IHC; ICC; IP.
MAA089Hu22 Monoclonal Antibody to Monocyte Chemotactic Protein 3 (MCP3) WB; IHC; ICC; IP.
Assay Kits SEA089Hu ELISA Kit for Monocyte Chemotactic Protein 3 (MCP3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA089Hu CLIA Kit for Monocyte Chemotactic Protein 3 (MCP3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA089Mu01 Recombinant Monocyte Chemotactic Protein 3 (MCP3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA089Mu02 Recombinant Monocyte Chemotactic Protein 3 (MCP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA089Mu01 Polyclonal Antibody to Monocyte Chemotactic Protein 3 (MCP3) WB; IHC; ICC; IP.
LAA089Mu71 Biotin-Linked Polyclonal Antibody to Monocyte Chemotactic Protein 3 (MCP3) WB; IHC; ICC.
PAA089Mu02 Polyclonal Antibody to Monocyte Chemotactic Protein 3 (MCP3) WB; IHC; ICC; IP.
Assay Kits SEA089Mu ELISA Kit for Monocyte Chemotactic Protein 3 (MCP3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA089Ra01 Recombinant Monocyte Chemotactic Protein 3 (MCP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA089Ra01 Polyclonal Antibody to Monocyte Chemotactic Protein 3 (MCP3) WB; IHC; ICC; IP.
MAA089Ra21 Monoclonal Antibody to Monocyte Chemotactic Protein 3 (MCP3) WB; IHC; ICC; IP.
Assay Kits SEA089Ra ELISA Kit for Monocyte Chemotactic Protein 3 (MCP3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines."Biochem. Biophys. Res. Commun. 191:535-542(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12."Genomics 21:403-408(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of the MCP-3 chemokine gene and regulation of its expression."Eur. Cytokine Netw. 4:99-110(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family."J. Exp. Med. 176:59-65(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3."FEBS Lett. 395:277-282(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy."Biochemistry 36:4412-4422(1997) [PubMed] [Europe PMC] [Abstract]
  9. , Submitted (AUG-1998) to the PDB data bank