Plasminogen Activator Inhibitor 1 (PAI1)

[Edit]

SERPINE1; PLANH1; Serpin Peptidase Inhibitor Clade E Member 1; Nexin,Plasminogen Activator Inhibitor Type 1 Serpin E1; Endothelial plasminogen activator inhibitor

Plasminogen Activator Inhibitor 1 (PAI1)

Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1).

The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators. PAI-1 is mainly produced by the endothelium (cells lining blood vessels), but is also secreted by other tissue types, such as adipose tissue.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA532Hu01Recombinant Plasminogen Activator Inhibitor 1 (PAI1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA532Hu01Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
MAA532Hu22Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
LAA532Hu71Biotin-Linked Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)IHC;WB;ELISA
LAA532Hu81FITC-Linked Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)IHC;ICC;IF;WB
MAA532Hu21Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA532HuELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1)Enzyme-linked immunosorbent assay
SCA532HuCLIA Kit for Plasminogen Activator Inhibitor 1 (PAI1)Chemiluminescent immunoassay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA532Mu01Recombinant Plasminogen Activator Inhibitor 1 (PAI1)SDS-PAGE; WB; ELISA; IP.
RPA532Mu02Recombinant Plasminogen Activator Inhibitor 1 (PAI1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA532Mu01Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
PAA532Mu02Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA532MuELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1)Enzyme-linked immunosorbent assay

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA532Ra01Recombinant Plasminogen Activator Inhibitor 1 (PAI1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA532Ra01Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
MAA532Ra21Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA532RaELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1)Enzyme-linked immunosorbent assay
SCA532RaCLIA Kit for Plasminogen Activator Inhibitor 1 (PAI1)Chemiluminescent immunoassay

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA532Rb01Recombinant Plasminogen Activator Inhibitor 1 (PAI1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA532Rb51Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
MAA532Rb21Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA532RbELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1)Enzyme-linked immunosorbent assay

Organism species: Rhesus monkey (Simian)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA532Si01Recombinant Plasminogen Activator Inhibitor 1 (PAI1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA532Si01Polyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
MAA532Si21Monoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA532SiELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1)Enzyme-linked immunosorbent assay

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Plasminogen Activator Inhibitor 1 (PAI1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Plasminogen Activator Inhibitor 1 (PAI1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Plasminogen Activator Inhibitor 1 (PAI1)CLIA Kit Customized Service Offer
n/aELISA Kit for Plasminogen Activator Inhibitor 1 (PAI1)ELISA Kit Customized Service Offer
  1. "Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family."EMBO J. 5:2539-2544(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns."Biochemistry 26:3763-3768(1987) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA cloning of human plasminogen activator-inhibitor from endothelial cells."J. Clin. Invest. 78:1673-1680(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Structure and expression of the human gene encoding plasminogen activator inhibitor, PAI-1."Gene 84:447-453(1989) [PubMed] [Europe PMC] [Abstract]
  5. "The organization of the human-plasminogen-activator-inhibitor-1 gene. Implications on the evolution of the serine-protease inhibitor family."Eur. J. Biochem. 176:609-616(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Human plasminogen activator inhibitor-1 gene. Promoter and structural gene nucleotide sequences."J. Biol. Chem. 263:9129-9141(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor."Proc. Natl. Acad. Sci. U.S.A. 83:6776-6780(1986) [PubMed] [Europe PMC] [Abstract]
  11. "Plasminogen activator inhibitor type-1: reactive center and amino-terminal heterogeneity determined by protein and cDNA sequencing."FEBS Lett. 209:213-218(1986) [PubMed] [Europe PMC] [Abstract]
  12. "cDNA cloning and expression in E. coli of a plasminogen activator inhibitor (PAI) related to a PAI produced by Hep G2 hepatoma cell."FEBS Lett. 210:11-16(1987) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of a PAI-1 binding site in vitronectin."Biochim. Biophys. Acta 1208:104-110(1994) [PubMed] [Europe PMC] [Abstract]
  14. "Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene."Blood 90:204-208(1997) [PubMed] [Europe PMC] [Abstract]
  15. "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein."J. Biol. Chem. 276:28889-28896(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity."Biochem. J. 390:231-242(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis of latency in plasminogen activator inhibitor-1."Nature 355:270-273(1992) [PubMed] [Europe PMC] [Abstract]
  19. "Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1."Nat. Struct. Biol. 2:891-897(1995) [PubMed] [Europe PMC] [Abstract]
  20. "Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide."Structure 6:627-636(1998) [PubMed] [Europe PMC] [Abstract]
  21. "The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion."Structure 7:111-118(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation."J. Mol. Biol. 297:683-695(2000) [PubMed] [Europe PMC] [Abstract]
  23. "Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer."Electrophoresis 18:686-689(1997) [PubMed] [Europe PMC] [Abstract]
  24. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  25. ErratumNat. Genet. 23:373-373(1999)