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Intercellular Adhesion Molecule 1 (ICAM1)

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CD54; BB2; P3.58; Human Rhinovirus Receptor; Major group rhinovirus receptor

Intercellular Adhesion Molecule 1 (ICAM1)
CCC A548
HGNC 5344
MGI 96392
PubMed 15853902
RGD 2857
UniProt P05362
Wiki ICAM-1

ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes.

When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues.ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA548Hu01 Recombinant Intercellular Adhesion Molecule 1 (ICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA548Hu02 Recombinant Intercellular Adhesion Molecule 1 (ICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA548Hu01 Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
MAA548Hu22 Monoclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
PAA548Hu02 Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
LAA548Hu71 Biotin-Linked Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC.
LAA548Hu81 FITC-Linked Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IF.
MAA548Hu21 Monoclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
MAA548Hu23 Monoclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
Assay Kits SEA548Hu ELISA Kit for Intercellular Adhesion Molecule 1 (ICAM1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA548Hu CLIA Kit for Intercellular Adhesion Molecule 1 (ICAM1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA548Mu01 Recombinant Intercellular Adhesion Molecule 1 (ICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA548Mu02 Recombinant Intercellular Adhesion Molecule 1 (ICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA548Mu01 Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
PAA548Mu02 Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
Assay Kits SEA548Mu ELISA Kit for Intercellular Adhesion Molecule 1 (ICAM1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA548Mu CLIA Kit for Intercellular Adhesion Molecule 1 (ICAM1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA548Ra01 Recombinant Intercellular Adhesion Molecule 1 (ICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA548Ra01 Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
MAA548Ra21 Monoclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
Assay Kits SEA548Ra ELISA Kit for Intercellular Adhesion Molecule 1 (ICAM1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA548Ra CLIA Kit for Intercellular Adhesion Molecule 1 (ICAM1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Hamster (Chinese hamster)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Intercellular Adhesion Molecule 1 (ICAM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intercellular Adhesion Molecule 1 (ICAM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intercellular Adhesion Molecule 1 (ICAM1) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA548Rb01 Recombinant Intercellular Adhesion Molecule 1 (ICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
CPA548Rb21 OVA Conjugated Intercellular Adhesion Molecule 1 (ICAM1) Immunogen; SDS-PAGE; WB.
Antibodies PAA548Rb51 Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
MAA548Rb21 Monoclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
PAA548Rb01 Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
Assay Kits SEA548Rb ELISA Kit for Intercellular Adhesion Molecule 1 (ICAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA548Ca01 Recombinant Intercellular Adhesion Molecule 1 (ICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA548Ca01 Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
MAA548Ca21 Monoclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
Assay Kits SEA548Ca ELISA Kit for Intercellular Adhesion Molecule 1 (ICAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA548Po01 Recombinant Intercellular Adhesion Molecule 1 (ICAM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA548Po01 Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC
MAA548Po21 Monoclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IP.
LAA548Po81 FITC-Linked Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) WB; IHC; ICC; IF.
Assay Kits SEA548Po ELISA Kit for Intercellular Adhesion Molecule 1 (ICAM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Intercellular Adhesion Molecule 1 (ICAM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1) Polyclonal Antibody Customized Service Offer
Assay Kits SEA548Bo ELISA Kit for Intercellular Adhesion Molecule 1 (ICAM1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM."Nature 331:624-627(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families."Cell 52:925-933(1988) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1."Proc. Natl. Acad. Sci. U.S.A. 86:4907-4911(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester."J. Immunol. 147:2777-2786(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Structural characteristics of the 5' region of the human ICAM-1 gene."Immunobiology 182:79-87(1990) [PubMed] [Europe PMC] [Abstract]
  8. "The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs)."J. Theor. Biol. 232:339-346(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The major human rhinovirus receptor is ICAM-1."Cell 56:839-847(1989) [PubMed] [Europe PMC] [Abstract]
  10. "A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection."Nature 344:70-72(1990) [PubMed] [Europe PMC] [Abstract]
  11. "MUC1 mucin core protein binds to the domain 1 of ICAM-1."Digestion 63 Suppl. 1:87-92(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1."J. Virol. 75:2444-2451(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  14. "MARCH-IX mediates ubiquitination and downregulation of ICAM-1."FEBS Lett. 581:45-51(2007) [PubMed] [Europe PMC] [Abstract]
  15. "RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration."J. Cell Biol. 178:1279-1293(2007) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  18. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1."Proc. Natl. Acad. Sci. U.S.A. 95:4134-4139(1998) [PubMed] [Europe PMC] [Abstract]
  24. "The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand."Proc. Natl. Acad. Sci. U.S.A. 95:4140-4145(1998) [PubMed] [Europe PMC] [Abstract]
  25. "Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor."EMBO J. 18:6249-6259(1999) [PubMed] [Europe PMC] [Abstract]
  26. "Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation."Cell 112:99-111(2003) [PubMed] [Europe PMC] [Abstract]
  27. "Structural basis for dimerization of ICAM-1 on the cell surface."Mol. Cell 14:269-276(2004) [PubMed] [Europe PMC] [Abstract]
  28. "The crystal structure of coxsackievirus A21 and its interaction with ICAM-1."Structure 13:1019-1033(2005) [PubMed] [Europe PMC] [Abstract]
  29. "Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster."Genomics 21:473-477(1994) [PubMed] [Europe PMC] [Abstract]
  30. "DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis."Hum. Genet. 97:15-20(1996) [PubMed] [Europe PMC] [Abstract]
  31. "A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya."Hum. Mol. Genet. 6:1357-1360(1997) [PubMed] [Europe PMC] [Abstract]
  32. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]