Keratin 10 (KRT10)

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K10; CK10; KPP; Cytokeratin 10; Epidermolytic Hyperkeratosis; Keratosis Palmaris Et Plantaris; Keratin, type I cytoskeletal 10

Keratin 10 (KRT10)

Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris), also known as KRT10, is a human gene.This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins.

Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB691Hu01Recombinant Keratin 10 (KRT10)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAB691Hu01Polyclonal Antibody to Keratin 10 (KRT10)WB, ICC, IHC-P, IHC-F, ELISA
MAB691Hu22Monoclonal Antibody to Keratin 10 (KRT10)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB691HuELISA Kit for Keratin 10 (KRT10)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Keratin 10 (KRT10)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Keratin 10 (KRT10)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Keratin 10 (KRT10)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Keratin 10 (KRT10)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 10 (KRT10)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB691Ra01Recombinant Keratin 10 (KRT10)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB691Ra01Polyclonal Antibody to Keratin 10 (KRT10)WB, ICC, IHC-P, IHC-F, ELISA
LAB691Ra71Biotin-Linked Polyclonal Antibody to Keratin 10 (KRT10)IHC;WB;ELISA
Assay Kitsn/aCLIA Kit for Keratin 10 (KRT10)CLIA Kit Customized Service Offer
n/aELISA Kit for Keratin 10 (KRT10)ELISA Kit Customized Service Offer
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  6. "Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing."J. Invest. Dermatol. 102:13-16(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats."Gene 116:245-251(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10."Science 330:94-97(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes."Cell 70:811-819(1992) [PubMed] [Europe PMC] [Abstract]
  14. "Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops."Proc. Natl. Acad. Sci. U.S.A. 89:910-914(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis."Science 257:1128-1130(1992) [PubMed] [Europe PMC] [Abstract]
  16. "Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis."Am. J. Hum. Genet. 54:179-190(1994) [PubMed] [Europe PMC] [Abstract]
  17. "Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity."J. Clin. Invest. 93:1533-1542(1994) [PubMed] [Europe PMC] [Abstract]
  18. "Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE)."J. Invest. Dermatol. 102:24-30(1994) [PubMed] [Europe PMC] [Abstract]
  19. "Genetic and clinical mosaicism in a type of epidermal nevus."N. Engl. J. Med. 331:1408-1415(1994) [PubMed] [Europe PMC] [Abstract]
  20. "A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma."J. Invest. Dermatol. 108:357-361(1997) [PubMed] [Europe PMC] [Abstract]
  21. "A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma."J. Invest. Dermatol. 111:1220-1223(1998) [PubMed] [Europe PMC] [Abstract]
  22. "A novel substitution in keratin 10 in epidermolytic hyperkeratosis."J. Invest. Dermatol. 112:506-508(1999) [PubMed] [Europe PMC] [Abstract]
  23. "Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis."Br. J. Dermatol. 164:442-447(2011) [PubMed] [Europe PMC] [Abstract]