Vinculin (VCL)
In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Its sequence is 20-30% homologous to α-catenin, which serves a similar function.
Vinculin is a 117 kDa cytoskeletal protein with 1066 amino acids. The protein contains an acidic N-terminal domain and a basic C-terminal domain separated by a proline-rich middle segment. Vinculin consists of a globular head domain that contains binding sites for talin and α-actinin as well as a tyrosine phosphorylation site, while the tail region contains binding sites for F-actin, paxillin and lipids.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB839Hu01Recombinant Vinculin (VCL)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB839Hu01Polyclonal Antibody to Vinculin (VCL)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAB839Hu22Monoclonal Antibody to Vinculin (VCL)WB, ICC, IHC-P, IHC-F, ELISA
LAB839Hu71Biotin-Linked Polyclonal Antibody to Vinculin (VCL)IHC;WB;ELISA
CAB839Hu01Anti-Vinculin (VCL) Polyclonal AntibodyLoading Control of WB
Assay KitsSEB839HuELISA Kit for Vinculin (VCL)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB839Mu01Recombinant Vinculin (VCL)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
RPB839Mu02Recombinant Vinculin (VCL)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB839Mu01Polyclonal Antibody to Vinculin (VCL)WB, ICC, IHC-P, IHC-F, ELISA
PAB839Mu02Polyclonal Antibody to Vinculin (VCL)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB839MuELISA Kit for Vinculin (VCL)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Vinculin (VCL)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Vinculin (VCL)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Vinculin (VCL)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Vinculin (VCL)CLIA Kit Customized Service Offer
n/aELISA Kit for Vinculin (VCL)ELISA Kit Customized Service Offer
  1. "Complete sequence of human vinculin and assignment of the gene to chromosome 10."Proc. Natl. Acad. Sci. U.S.A. 87:5667-5671(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter."J. Biol. Chem. 268:4318-4325(1993) [PubMed] [Europe PMC] [Abstract]