Vinculin (VCL)

In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Its sequence is 20-30% homologous to alpha-catenin, which serves a similar function.

Vinculin is a 117 kDa cytoskeletal protein with 1066 amino acids. The protein contains an acidic N-terminal domain and a basic C-terminal domain separated by a proline-rich middle segment. Vinculin consists of a globular head domain that contains binding sites for talin and alpha-actinin as well as a tyrosine phosphorylation site, while the tail region contains binding sites for F-actin, paxillin and lipids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB839Hu01 Recombinant Vinculin (VCL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB839Hu01 Polyclonal Antibody to Vinculin (VCL) WB; IHC; ICC; IP.
MAB839Hu22 Monoclonal Antibody to Vinculin (VCL) WB; IHC; ICC; IP.
LAB839Hu71 Biotin-Linked Polyclonal Antibody to Vinculin (VCL) WB; IHC; ICC.
CAB839Hu22 Anti-Vinculin (VCL) Monoclonal Antibody Loading Control of WB.
CAB839Hu01 Anti-Vinculin (VCL) Polyclonal Antibody Loading Control of WB.
Assay Kits SEB839Hu ELISA Kit for Vinculin (VCL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB839Mu01 Recombinant Vinculin (VCL) Positive Control; Immunogen; SDS-PAGE; WB.
RPB839Mu02 Recombinant Vinculin (VCL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB839Mu01 Polyclonal Antibody to Vinculin (VCL) WB; IHC; ICC; IP.
PAB839Mu02 Polyclonal Antibody to Vinculin (VCL) WB; IHC; ICC; IP.
Assay Kits SEB839Mu ELISA Kit for Vinculin (VCL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vinculin (VCL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vinculin (VCL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vinculin (VCL) Polyclonal Antibody Customized Service Offer
Assay Kits SEB839Ra ELISA Kit for Vinculin (VCL) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complete sequence of human vinculin and assignment of the gene to chromosome 10."Proc. Natl. Acad. Sci. U.S.A. 87:5667-5671(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter."J. Biol. Chem. 268:4318-4325(1993) [PubMed] [Europe PMC] [Abstract]