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In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Its sequence is 20-30% homologous to alpha-catenin, which serves a similar function.
Vinculin is a 117 kDa cytoskeletal protein with 1066 amino acids. The protein contains an acidic N-terminal domain and a basic C-terminal domain separated by a proline-rich middle segment. Vinculin consists of a globular head domain that contains binding sites for talin and alpha-actinin as well as a tyrosine phosphorylation site, while the tail region contains binding sites for F-actin, paxillin and lipids.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB839Hu01 | Recombinant Vinculin (VCL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB839Hu02 | Recombinant Vinculin (VCL) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB839Hu01 | Polyclonal Antibody to Vinculin (VCL) | WB; IHC; ICC; IP. |
| MAB839Hu22 | Monoclonal Antibody to Vinculin (VCL) | WB; IHC; ICC; IP. | |
| LAB839Hu71 | Biotin-Linked Polyclonal Antibody to Vinculin (VCL) | WB; IHC; ICC. | |
| CAB839Hu22 | Anti-Vinculin (VCL) Monoclonal Antibody | Loading Control of WB | |
| CAB839Hu01 | Anti-Vinculin (VCL) Polyclonal Antibody | Loading Control of WB. | |
| CAB839Mi22 | Anti-Vinculin (VCL) Monoclonal Antibody | Loading Control of WB | |
| MAB839Hu21 | Monoclonal Antibody to Vinculin (VCL) | WB; IHC; ICC; IP. | |
| PAB839Hu02 | Polyclonal Antibody to Vinculin (VCL) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB839Hu | ELISA Kit for Vinculin (VCL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| AEB839Hu | ELISA Kit for Anti-Vinculin Antibody (Anti-VCL) | Enzyme-linked immunosorbent assay for Antibody Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB839Mu01 | Recombinant Vinculin (VCL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB839Mu02 | Recombinant Vinculin (VCL) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB839Mu01 | Polyclonal Antibody to Vinculin (VCL) | WB; IHC; ICC; IP. |
| PAB839Mu02 | Polyclonal Antibody to Vinculin (VCL) | WB; IHC; ICC; IP. | |
| CAB839Mi22 | Anti-Vinculin (VCL) Monoclonal Antibody | Loading Control of WB | |
| Assay Kits | SEB839Mu | ELISA Kit for Vinculin (VCL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Vinculin (VCL) | Recombinant Protein Customized Service Offer |
| Antibodies | CAB839Mi22 | Anti-Vinculin (VCL) Monoclonal Antibody | Loading Control of WB |
| Assay Kits | SEB839Ra | ELISA Kit for Vinculin (VCL) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Complete sequence of human vinculin and assignment of the gene to chromosome 10."Proc. Natl. Acad. Sci. U.S.A. 87:5667-5671(1990) [PubMed] [Europe PMC] [Abstract]
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter."J. Biol. Chem. 268:4318-4325(1993) [PubMed] [Europe PMC] [Abstract]