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Monoclonal Antibody to Epiregulin (EREG)

EPR; ER; Proepiregulin

  • Product No.MAB945Ra21
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • SourceMonoclonal antibody preparation
  • HostMouse
  • Potency (Clone Number)n/a
  • Ig Isotype IgG
  • PurificationAntigen-specific affinity chromatography followed by Protein A affinity chromatography
  • LabelNone
  • Immunogen n/a
  • Buffer FormulationPBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
  • TraitsLiquid
  • Concentration1mg/mL
  • Organism Species Moren/a
  • ApplicationsWB; IHC; ICC; IP.
    If the antibody is used in flow cytometry, please check FCM antibodies.
  • Downloadn/a
  • UOM 20µl100µl 200µl 1ml 10ml
  • FOB US$ 115  US$ 267  US$ 382  US$ 955  US$ 3820 
    For more details, please contact local distributors!

SPECIFITY

The antibody is a mouse monoclonal antibody raised against EREG. It has been selected for its ability to recognize EREG in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.2-2µg/mL;1:500-5000
Immunohistochemistry: 5-20µg/mL;1:50-200
Immunocytochemistry: 5-20µg/mL;1:50-200
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
British Journal of Cancer Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells Nature: 2012103
J Pharmacol Exp Ther. Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Pubmed: 24309559
Molecular Carcinogenesis The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines Pubmed:23625689
Am J Physiol Gastrointest Liver Physiol. Epiregulin promotes the emergence and proliferation of adult liver progenitor cells. Pubmed:24812054
European Review for Medical and Pharmacological Sciences Epiregulin-loaded PLGA nanoparticles increase human keratinocytes proliferation: preliminary data pubmed:27383296
Oncotarget Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation PMC5593575
American journal of respiratory cell and molecular biology Potential Involvement of the Epidermal Growth Factor Receptor Ligand Epiregulin and Matrix Metalloproteinase-1 in Pathogenesis of Chronic Rhinosinusitis pubmed:28398769
International Journal of Cancer Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer Pubmed: 30252132
Epiregulin is released from intervertebral disks and induces spontaneous activity in pain pathways Doi: 10.1097/PR9.0000000000000718
Cell proliferation Epiregulin enhances odontoblastic differentiation of dental pulp stem cells via activating MAPK signalling pathway Pubmed: 31454111
International Journal of Molecular Sciences Promising Therapeutic Efficacy of GC1118, an Anti-EGFR Antibody, against KRAS Mutation-Driven Colorectal Cancer Patient-Derived Xenografts Pubmed: 31771279
Neoplasia Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine Pubmed: 33212364
Reprod Sci Compromised Cumulus-Oocyte Complex Matrix Organization and Expansion in Women with PCOS 34748173
Tissue and Cell MiR-192-5p suppresses M1 macrophage polarization via epiregulin (EREG) downregulation in gouty arthritis 34715618
Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
RPB945Ra01 Recombinant Epiregulin (EREG) Positive Control; Immunogen; SDS-PAGE; WB.
PAB945Ra01 Polyclonal Antibody to Epiregulin (EREG) WB; IHC; ICC; IP.
MAB945Ra21 Monoclonal Antibody to Epiregulin (EREG) WB; IHC; ICC; IP.
SEB945Ra ELISA Kit for Epiregulin (EREG) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB945Ra CLIA Kit for Epiregulin (EREG) Chemiluminescent immunoassay for Antigen Detection.
LMB945Ra Multiplex Assay Kit for Epiregulin (EREG) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.