Polyclonal Antibody to Complement Factor I (CFI)

CF-I; C3b-INA; FI; IF; KAF; Factor I; Konglutinogen-Activating Factor; C3b-Inactivator; C3B/C4B inactivator

SPECIFITY

The antibody is a rabbit polyclonal antibody raised against CFI. It has been selected for its ability to recognize CFI in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.5-2µg/mL
Immunohistochemistry: 5-20µg/mL
Immunocytochemistry: 5-20µg/mL
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

GIVEAWAYS

INCREMENT SERVICES

Magazine Citations
J Thromb Haemost A case report of thrombotic microangiopathy without renal involvement carrying two novel mutations in complement-regulator genes PubMed: 26613809
Pediatr Int Atypical hemolytic uremic syndrome: Korean pediatric series PubMed: 25443527
United States Patent Application  NOVEL ASSAY y2016:139118
Researchgate Compliment factor i bioassay US20170285024
PLoS One A monoclonal antibody targeting amyloid β (Aβ) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and … Pubmed:29782502
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE The importance of sialic acid, pH and ion concentration on the interaction of uromodulin and complement factor H 33788378
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