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NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye
On July 19, 2020, professor Wei Chi from Zhongshan Ophthalmic Center of Sun Yat-sen University published a paper on The Ocular Surface. The paper titled NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye.The recombinant protein kit (GSDMD, RPE529Mu01) of Cloud-Clone brand was chosed to rescue GSDMD KO mice in this article, we are so proud for supporting the reaserchers.Dry eye disease (DED) is a common and multifactor-induced autoimmune ocular surface disease. Environmental factors, such as desiccating stress (DS) and hyperosmolarity, affect the corneal epithelium to induce ocular surface inflammation in DED......
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Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis
In July, 2020, professor Kai-Fu Tang from the First Affiliated Hospital of Wenzhou Medical University published a paper on Theranostics. The paper titled Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis.The ELISA kit (8OHdG, CEA660Ge) of Cloud-Clone brand was chosed to determine the concentation of 8OHdG in this article, we are so proud for supporting the reaserchers.Chronic inflammation is known to promote carcinogenesis; Dicer heterozygous mice are more likely to develop colitis-associated tumors. This study investigates whether Dicer is downregulated in inflamed colon tissues before malignancy occurs and whether ......
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ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
On July 15, 2020, professor Samuel C Mok from The University of Texas MD Anderson Cancer Center coauthored with professor Deepak Nagrath from University of Michigan published a paper on Nature communications. The paper titled ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment.The ELISA kit ((ITLN1, SEA933Mu) of Cloud-Clone brand was chosed to determine the concentation of ITLN1 in this article, we are so proud for supporting Advanced ovarian cancer usually spreads to the omentum. However, the omental cell-derived molecular determinants modulating its progression have not been thoroughly characterized. Here, we show that ......
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RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis
On July 7, 2020, professor Kenta Maruyama from Osaka University WPI Immunology Frontier Research Center published a paper on Cell. The paper titled RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis.The ELISA kit (CTX1, CEA665Mu) of Cloud-Clone brand was chosed to determine the concentation of PVR in this article, we are so proud for supporting the reaserchers.Gastrointestinal enterochromaffin cells regulate bone and gut homeostasis via serotonin (5-hydroxytryptamine [5-HT]) production. A recent report suggested that gut microbes regulate 5-HT levels; however, the precise underlying molecular mechanisms are unexplored. Here, we reveal that the cation channel Pie......
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Integrative Proteomic Characterization of Human Lung Adenocarcinoma
On July 9, 2020, professor Minjia Tan from Shanghai institute of materia medica of Chinese academy of sciences, professor Ting Xiao from Chinese academy of medical sciences and Peking union medical college, professor Fuchu He and Yi Wang from Beijing institute of lifeomics and professor Jing Li from Shanghai Jiao Tong university co-authored published a paper on Cell. The paper titled Integrative Proteomic Characterization of Human Lung Adenocarcinoma.The ELISA kit (HSP90aB1, SED522Hu) of Cloud-Clone brand was chosed to determine the concentation of PVR in this article, we are so proud for supporting the reaserchers.Genomic studies of lung adenocarcinoma (LUAD) have advanced our under......
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Nectin-2 Expression on Malignant Plasma Cells Is Associated with Better Response to TIGIT Blockade in Multiple Myeloma
On June 8, 2020, professor Carlos Fernández de Larrea from xospital Clínic de Barcelona published a paper titled Nectin-2 Expression on malignant plasma cells is associated with better response to TIGIT blockade in multiple myeloma on Clinical cancer research.The ELISA kit (PVR, SEB550Hu) of Cloud-Clone brand was chosed to determine the concentation of PVR in this article, we are so proud for supporting the reaserchers.T-cell immunoreceptor with Ig and ITIM domain (TIGIT) blockade could represent an alternative therapeutic option to release the immune response in patients with multiple myeloma. Here we analyzed the expression of TIGIT and its ligands poliovirus receptor (PVR) and......