Semaphorin 3A (SEMA3A)

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SEMAL; Hsema-I; Hsema-III; SEMA1; SEMAD; SEMAIII; SemD; Coll-1; Sema Domain,Immunoglobulin Domain(Ig),Transmembrane Domain(TM)and Short Cytoplasmic Domain 3A

Semaphorin 3A (SEMA3A)
SEMA3A is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.The first of the CRMP proteins, CRMP2, was identified as an intracellular messenger required for the growth cone-collapse induced by semaphorin 3A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL917Hu01 Recombinant Semaphorin 3A (SEMA3A) Positive Control; Immunogen; SDS-PAGE; WB.
RPL917Hu02 Recombinant Semaphorin 3A (SEMA3A) Positive Control; Immunogen; SDS-PAGE; WB.
APL917Hu02 Active Semaphorin 3A (SEMA3A) Cell culture; Activity Assays.
APL917Hu01 Active Semaphorin 3A (SEMA3A) Cell culture; Activity Assays.
Antibodies PAL917Hu01 Polyclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC; IP.
LAL917Hu71 Biotin-Linked Polyclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC.
PAL917Hu02 Polyclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC; IP.
LAL917Hu72 Biotin-Linked Monoclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC.
MAL917Hu21 Monoclonal Antibody to Semaphorin 3A (SEMA3A) WB,IHC
MAL917Hu22 Monoclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC; IP.
MAL917Hu23 Monoclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC; IP.
MAL917Hu24 Monoclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC; IP.
Assay Kits SEL917Hu ELISA Kit for Semaphorin 3A (SEMA3A) Enzyme-linked immunosorbent assay for Antigen Detection.
SCL917Hu CLIA Kit for Semaphorin 3A (SEMA3A) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL917Mu01 Recombinant Semaphorin 3A (SEMA3A) Positive Control; Immunogen; SDS-PAGE; WB.
RPL917Mu02 Recombinant Semaphorin 3A (SEMA3A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL917Mu01 Polyclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC; IP.
PAL917Mu02 Polyclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC; IP.
LAL917Mu71 Biotin-Linked Polyclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC.
Assay Kits SEL917Mu ELISA Kit for Semaphorin 3A (SEMA3A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL917Ra01 Recombinant Semaphorin 3A (SEMA3A) Positive Control; Immunogen; SDS-PAGE; WB.
APL917Ra01 Active Semaphorin 3A (SEMA3A) Cell culture; Activity Assays.
Antibodies PAL917Ra01 Polyclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC; IP.
MAL917Ra21 Monoclonal Antibody to Semaphorin 3A (SEMA3A) WB; IHC; ICC; IP.
Assay Kits SEL917Ra ELISA Kit for Semaphorin 3A (SEMA3A) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules."Cell 75:1389-1399(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development."Hum. Reprod. 27:1460-1465(2012) [PubMed] [Europe PMC] [Abstract]
  4. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
  6. "SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome." PLoS Genet. 8:E1002896-E1002896(2012) [PubMed] [Europe PMC] [Abstract]
  7. "The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients." J. Clin. Endocrinol. Metab. 99:E2138-2143(2014) [PubMed] [Europe PMC] [Abstract]