Mucin 1 (MUC1)

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CD227; EMA; H23AG; KL-6; PEM; PEMT; PUM; CA15-3; Cancer antigen 15-3; Carcinoma-associated mucin; Episialin; Peanut-reactive urinary mucin; Polymorphic epithelial mucin

Mucin 1 (MUC1)

 MUC1 is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 amino acid variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals.

The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA413Hu01Recombinant Mucin 1 (MUC1)SDS-PAGE; WB; ELISA; IP; CoIP; Reporter Assays; Purification; Amine Reactive Labeling.
RPA413Hu02Recombinant Mucin 1 (MUC1)SDS-PAGE; WB; ELISA; IP.
RPA413Hu03Recombinant Mucin 1 (MUC1)SDS-PAGE; WB; ELISA; IP.
CPA413Hu21OVA Conjugated Mucin 1 (MUC1)Immunogen; Coating Antigen; Blocking Peptide; ELISA.
SPA413Hu02Synthetic Mucin 1 (MUC1)Immunogen; Coating Antigen; Blocking Peptide; ELISA.
AntibodiesPAA413Hu01Polyclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
MAA413Hu22Monoclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
PAA413Hu02Polyclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
PAA413Hu03Polyclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
LAA413Hu81FITC-Linked Polyclonal Antibody to Mucin 1 (MUC1)IHC;ICC;IF;WB
LAA413Hu71Biotin-Linked Polyclonal Antibody to Mucin 1 (MUC1)IHC;WB;ELISA
PAA413Hu08Polyclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA413HuELISA Kit for Mucin 1 (MUC1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA413Mu01Recombinant Mucin 1 (MUC1)SDS-PAGE; WB; ELISA; IP.
RPA413Mu02Recombinant Mucin 1 (MUC1)SDS-PAGE; WB; ELISA; IP.
RPA413Mu03Recombinant Mucin 1 (MUC1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA413Mu01Polyclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
LAA413Mu71Biotin-Linked Polyclonal Antibody to Mucin 1 (MUC1)IHC;WB;ELISA
PAA413Mu02Polyclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
PAA413Mu03Polyclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA413MuELISA Kit for Mucin 1 (MUC1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA413Ra01Recombinant Mucin 1 (MUC1)SDS-PAGE; WB; ELISA; IP.
RPA413Ra02Recombinant Mucin 1 (MUC1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA413Ra01Polyclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
MAA413Ra21Monoclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
PAA413Ra02Polyclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA413RaELISA Kit for Mucin 1 (MUC1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA413Bo01Recombinant Mucin 1 (MUC1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA413Bo01Polyclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
MAA413Bo22Monoclonal Antibody to Mucin 1 (MUC1)WB, ICC, IHC-P, IHC-F, ELISA
LAA413Bo71Biotin-Linked Polyclonal Antibody to Mucin 1 (MUC1)IHC;WB;ELISA
Assay Kitsn/aCLIA Kit for Mucin 1 (MUC1)CLIA Kit Customized Service Offer
n/aELISA Kit for Mucin 1 (MUC1)ELISA Kit Customized Service Offer
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  29. "Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin."Mol. Cell. Biol. 18:7216-7224(1998) [PubMed] [Europe PMC] [Abstract]
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  39. "MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation."Cancer Biol. Ther. 2:702-706(2003) [PubMed] [Europe PMC] [Abstract]
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  46. ErratumJ. Biol. Chem. 280:28827-28827(2005)
  47. "Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profiles."Glycobiology 15:1111-1124(2005) [PubMed] [Europe PMC] [Abstract]
  48. "MUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells."J. Leukoc. Biol. 77:90-99(2005) [PubMed] [Europe PMC] [Abstract]
  49. "Recycling of MUC1 is dependent on its palmitoylation."J. Biol. Chem. 281:12112-12122(2006) [PubMed] [Europe PMC] [Abstract]
  50. "MUC1 oncoprotein stabilizes and activates estrogen receptor alpha."Mol. Cell 21:295-305(2006) [PubMed] [Europe PMC] [Abstract]
  51. "MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism."Biochim. Biophys. Acta 1773:1028-1038(2007) [PubMed] [Europe PMC] [Abstract]
  52. "Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene."Cancer Res. 67:1853-1858(2007) [PubMed] [Europe PMC] [Abstract]
  53. "Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells."Cancer Res. 67:5201-5210(2007) [PubMed] [Europe PMC] [Abstract]
  54. "MUC1 is a novel regulator of ErbB1 receptor trafficking."Oncogene 26:1693-1701(2007) [PubMed] [Europe PMC] [Abstract]
  55. "CA 15-3: uses and limitation as a biomarker for breast cancer."Clin. Chim. Acta 411:1869-1874(2010) [PubMed] [Europe PMC] [Abstract]
  56. "Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing." Nat. Genet. 45:299-303(2013) [PubMed] [Europe PMC] [Abstract]
  57. "N-glycosylation of the MUC1 mucin in epithelial cells and secretions."Glycobiology 16:623-634(2006) [PubMed] [Europe PMC] [Abstract]