Beta Catenin (β-catenin)


CTNNb1; bCat; b-Cat; CTNN-B1; Catenin Beta 1; Cadherin-Associated Protein

Beta Catenin (β-catenin)

Beta-catenin(or β-catenin)  is a subunit of the cadherin protein complex. In Drosophila, the homologous protein is called armadillo. Beta-catenin has been implicated as an integral component in the Wnt signaling pathway.When beta-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding.

An increase in beta-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When beta-catenin is not associated with cadherins and alpha-catenin, it can interact with other proteins such as ICAT and APC.

Organism species: Homo sapiens (Human)

Proteins RPB021Hu01 Recombinant Beta Catenin (β-catenin) Positive Control; Immunogen; SDS-PAGE; WB.
RPB021Hu02 Recombinant Beta Catenin (β-catenin) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB021Hu01 Polyclonal Antibody to Beta Catenin (β-catenin) WB; IHC; ICC; IP.
MAB021Hu22 Monoclonal Antibody to Beta Catenin (β-catenin) WB; IHC; ICC; IP.
CAB021Hu22 Anti-Beta Catenin (β-catenin) Monoclonal Antibody Loading Control of WB
CAB021Hu01 Anti-Beta Catenin (β-catenin) Polyclonal Antibody Loading Control of WB.
CAB021Mi01 Anti-Beta Catenin (β-catenin) Polyclonal Antibody Loading Control of WB.
CAB021Mi22 Anti-Beta Catenin (β-catenin) Monoclonal Antibody Loading Control of WB
MAB021Hu21 Monoclonal Antibody to Beta Catenin (β-catenin) WB; IHC; ICC; IP.
MAB021Hu23 Monoclonal Antibody to Beta Catenin (β-catenin) WB; IHC; ICC; IP.
Assay Kits SEB021Hu ELISA Kit for Beta Catenin (β-catenin) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

Proteins RPB021Mu01 Recombinant Beta Catenin (β-catenin) Positive Control; Immunogen; SDS-PAGE; WB.
RPB021Mu02 Recombinant Beta Catenin (β-catenin) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB021Mu01 Polyclonal Antibody to Beta Catenin (β-catenin) WB; IHC; ICC; IP.
PAB021Mu02 Polyclonal Antibody to Beta Catenin (β-catenin) WB; IHC; ICC; IP.
Assay Kits SEB021Mu ELISA Kit for Beta Catenin (β-catenin) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

Proteins RPB021Ra01 Recombinant Beta Catenin (β-catenin) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB021Ra01 Polyclonal Antibody to Beta Catenin (β-catenin) WB; IHC; ICC; IP.
MAB021Ra21 Monoclonal Antibody to Beta Catenin (β-catenin) WB; IHC; ICC; IP.
CAB021Mi22 Anti-Beta Catenin (β-catenin) Monoclonal Antibody Loading Control of WB
Assay Kits SEB021Ra ELISA Kit for Beta Catenin (β-catenin) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton."J. Cell Biol. 127:2061-2069(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells."Cancer Res. 62:2744-2748(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion."FEBS Lett. 355:195-200(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations."Nat. Genet. 15:170-174(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene."Cancer Res. 59:918-923(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration."J. Biol. Chem. 274:10173-10183(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Hot spots in beta-catenin for interactions with LEF-1, conductin and APC."Nat. Struct. Biol. 7:800-807(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles."Br. J. Dermatol. 145:576-581(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Chromatin-specific regulation of LEF-1-beta-catenin transcription activation and inhibition in vitro."Genes Dev. 15:3342-3354(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of beta-catenin structure and activity by tyrosine phosphorylation."J. Biol. Chem. 276:20436-20443(2001) [PubMed] [Europe PMC] [Abstract]
  14. "AlphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion."J. Cell Sci. 114:3177-3188(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses."Mol. Cell 7:915-926(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein."Mol. Cell 7:927-936(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion."Oncogene 20:4249-4257(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin."Biochemistry 41:15854-15860(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Characterisation of the phosphorylation of beta-catenin at the GSK-3 priming site Ser45."Biochem. Biophys. Res. Commun. 294:324-328(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape."Cell 110:789-799(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Identification of two novel regulated serines in the N-terminus of beta-catenin."Exp. Cell Res. 276:264-272(2002) [PubMed] [Europe PMC] [Abstract]
  22. "Wnt signaling controls the phosphorylation status of beta-catenin."J. Biol. Chem. 277:17901-17905(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells."J. Cell Sci. 115:2771-2780(2002) [PubMed] [Europe PMC] [Abstract]
  24. "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)."Oncogene 21:7067-7076(2002) [PubMed] [Europe PMC] [Abstract]
  25. "The emergence of protocadherin-PC expression during the acquisition of apoptosis-resistance by prostate cancer cells."Oncogene 21:7861-7871(2002) [PubMed] [Europe PMC] [Abstract]
  26. "EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma."Hepatology 38:178-186(2003) [PubMed] [Europe PMC] [Abstract]
  27. "Regulation of beta-catenin signaling in the Wnt pathway."Biochem. Biophys. Res. Commun. 268:243-248(2000) [PubMed] [Europe PMC] [Abstract]
  28. "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction."Mol. Cell. Biol. 23:2287-2297(2003) [PubMed] [Europe PMC] [Abstract]
  29. "Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells."Mol. Biol. Cell 15:397-406(2004) [PubMed] [Europe PMC] [Abstract]
  30. "E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion."Cancer Res. 66:10007-10015(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  32. "The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus."EMBO J. 25:3275-3285(2006) [PubMed] [Europe PMC] [Abstract]
  33. "MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism."Biochim. Biophys. Acta 1773:1028-1038(2007) [PubMed] [Europe PMC] [Abstract]
  34. "The Kruppel-like zinc finger protein Glis2 functions as a negative modulator of the Wnt/beta-catenin signaling pathway."FEBS Lett. 581:858-864(2007) [PubMed] [Europe PMC] [Abstract]
  35. "cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells."J. Cell. Biochem. 100:738-749(2007) [PubMed] [Europe PMC] [Abstract]
  36. "The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity."Proc. Natl. Acad. Sci. U.S.A. 104:20344-20349(2007) [PubMed] [Europe PMC] [Abstract]
  37. "beta-Catenin is a Nek2 substrate involved in centrosome separation."Genes Dev. 22:91-105(2008) [PubMed] [Europe PMC] [Abstract]
  38. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  39. "Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells."Mol. Cancer Res. 6:1421-1430(2008) [PubMed] [Europe PMC] [Abstract]
  40. "CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes."Mol. Cell. Biol. 28:3894-3904(2008) [PubMed] [Europe PMC] [Abstract]
  41. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  42. "The kinase TNIK is an essential activator of Wnt target genes."EMBO J. 28:3329-3340(2009) [PubMed] [Europe PMC] [Abstract]
  43. "Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells."J. Biol. Chem. 284:2012-2022(2009) [PubMed] [Europe PMC] [Abstract]
  44. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  45. "Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation."Biochem. Biophys. Res. Commun. 394:966-971(2010) [PubMed] [Europe PMC] [Abstract]
  46. "The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5."J. Biol. Chem. 285:12426-12434(2010) [PubMed] [Europe PMC] [Abstract]
  47. "Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction."J. Biol. Chem. 285:4213-4223(2010) [PubMed] [Europe PMC] [Abstract]
  48. "Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling."Mol. Biol. Rep. 37:2415-2421(2010) [PubMed] [Europe PMC] [Abstract]
  49. "Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6."J. Cell Sci. 123:236-245(2010) [PubMed] [Europe PMC] [Abstract]
  50. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  51. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  52. "Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization."Cell. Signal. 23:911-919(2011) [PubMed] [Europe PMC] [Abstract]
  53. "Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling."EMBO Rep. 12:43-49(2011) [PubMed] [Europe PMC] [Abstract]
  54. "Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor."J. Biol. Chem. 286:12450-12460(2011) [PubMed] [Europe PMC] [Abstract]
  55. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  56. "The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells."Cell Cycle 11:2206-2215(2012) [PubMed] [Europe PMC] [Abstract]
  57. "Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling."EMBO Rep. 13:750-758(2012) [PubMed] [Europe PMC] [Abstract]
  58. "Beta-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells."Gastroenterology 142:572-581(2012) [PubMed] [Europe PMC] [Abstract]
  59. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]
  60. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  61. "beta-catenin is O-GlcNAc glycosylated at Serine 23: implications for beta-catenin's subcellular localization and transactivator function."Exp. Cell Res. 321:153-166(2014) [PubMed] [Europe PMC] [Abstract]
  62. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  63. "The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of beta-catenin."Mol. Cell. Biol. 34:4355-4366(2014) [PubMed] [Europe PMC] [Abstract]
  64. "Crystal structure of a beta-catenin/Tcf complex."Cell 103:885-896(2000) [PubMed] [Europe PMC] [Abstract]
  65. "Tcf4 can specifically recognize beta-catenin using alternative conformations."Nat. Struct. Biol. 8:1048-1052(2001) [PubMed] [Europe PMC] [Abstract]
  66. "Structure of a human Tcf4-beta-catenin complex."Nat. Struct. Biol. 8:1053-1057(2001) [PubMed] [Europe PMC] [Abstract]
  67. "The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT."Mol. Cell 10:563-571(2002) [PubMed] [Europe PMC] [Abstract]
  68. "Crystal structure of a beta-catenin/BCL9/Tcf4 complex."Mol. Cell 24:293-300(2006) [PubMed] [Europe PMC] [Abstract]
  69. "Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC."Science 275:1787-1790(1997) [PubMed] [Europe PMC] [Abstract]
  70. "Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene."Cancer Res. 59:269-273(1999) [PubMed] [Europe PMC] [Abstract]
  71. "Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma."Genes Chromosomes Cancer 25:399-402(1999) [PubMed] [Europe PMC] [Abstract]
  72. "Mutational analysis of beta-catenin gene in Japanese ovarian carcinomas: frequent mutations in endometrioid carcinomas."Jpn. J. Cancer Res. 90:510-515(1999) [PubMed] [Europe PMC] [Abstract]
  73. "A novel case of a sporadic desmoid tumour with mutation of the beta catenin gene."J. Clin. Pathol. 52:695-696(1999) [PubMed] [Europe PMC] [Abstract]
  74. "A common human skin tumour is caused by activating mutations in beta-catenin."Nat. Genet. 21:410-413(1999) [PubMed] [Europe PMC] [Abstract]
  75. "Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity."Oncogene 18:4044-4046(1999) [PubMed] [Europe PMC] [Abstract]
  76. "APC mutations in sporadic medulloblastomas."Am. J. Pathol. 156:433-437(2000) [PubMed] [Europe PMC] [Abstract]
  77. "De novo mutations in beta-catenin (CTNNB1) appear to be a frequent cause of intellectual disability: expanding the mutational and clinical spectrum." Hum. Genet. 134:97-109(2015) [PubMed] [Europe PMC] [Abstract]