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Active Interleukin 11 (IL11)

AGIF; Adipogenesis Inhibitory Factor; Oprelvekin

ACTIVITY TEST

Interleukin 11 (IL-11) is a multifunctional cytokine. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses and participate in the regulation of bone cell proliferation and differentiation. Besides, IL-11 has been proved to promote cell proliferation of TF-1 cells. 2x104 TF-1 cells were seeded into a well of 96-well plates and allowed to attach, replaced with various concentrations of recombinant human TRAIL. After incubated for 72 hours, the 96-well plate was read at OD450 nm. The result was shown in Figure1. It was obvious that recombinant IL-11 protein significantly increased cell viability of TF-1 cells. Its EC50 is 0.5677μg/mL.

USAGE

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Molecular Medicine Reports Regulatory effect of chemerin and therapeutic efficacy of chemerin‑9 in pancreatogenic diabetes mellitus Pubmed: 31922216
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