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Monoclonal Antibody to Topoisomerase II (TOP2)

DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme

  • Product No.MAA792Ra21
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • SourceMonoclonal antibody preparation
  • HostMouse
  • Potency (Clone Number)n/a
  • Ig Isotype IgG
  • PurificationAntigen-specific affinity chromatography followed by Protein A affinity chromatography
  • LabelNone
  • Immunogen n/a
  • Buffer FormulationPBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
  • TraitsLiquid
  • Concentration1mg/mL
  • Organism Species Moren/a
  • ApplicationsWB; IHC; ICC; IP.
    If the antibody is used in flow cytometry, please check FCM antibodies.
  • Downloadn/a
  • UOM 20µl100µl 200µl 1ml 10ml
  • FOB US$ 109  US$ 253  US$ 362  US$ 905  US$ 3620 
    For more details, please contact local distributors!

SPECIFITY

The antibody is a mouse monoclonal antibody raised against TOP2. It has been selected for its ability to recognize TOP2 in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.2-2µg/mL;1:500-5000
Immunohistochemistry: 5-20µg/mL;1:50-200
Immunocytochemistry: 5-20µg/mL;1:50-200
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Journal of Experimental & Clinical Cancer Research Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II pubmed:27852319
Bioorganic & Medicinal Chemistry Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition. pubmed:28094224
European Journal of Medicinal Chemistry Antiproliferative activity of diarylnaphthylpyrrolidine derivative via dual target inhibition Pubmed: 31884407
Int J Mol Sci 2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule Pubmed:35456915
Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
RPA792Ra01 Recombinant Topoisomerase II (TOP2) Positive Control; Immunogen; SDS-PAGE; WB.
PAA792Ra01 Polyclonal Antibody to Topoisomerase II (TOP2) IHC
MAA792Ra21 Monoclonal Antibody to Topoisomerase II (TOP2) WB; IHC; ICC; IP.
SEA792Ra ELISA Kit for Topoisomerase II (TOP2) Enzyme-linked immunosorbent assay for Antigen Detection.
CMA792Ra Multiplex Assay Kit for Topoisomerase II (TOP2) ,etc. by CBA (Cytometric Bead Array) FLIA Kit for Antigen Detection.
LMA792Ra Multiplex Assay Kit for Topoisomerase II (TOP2) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.