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Monoclonal Antibody to Occludin (OCLN)

Tight Junction Protein Occludin TM4 Minus

  • Product No.MAC228Ra22
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • SourceMonoclonal antibody preparation
  • HostMouse
  • Potency (Clone Number)C16
  • Ig Isotype IgG
  • PurificationAntigen-specific affinity chromatography followed by Protein A affinity chromatography
  • LabelNone
  • Immunogen n/a
  • Buffer FormulationPBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
  • TraitsLiquid
  • Concentration1mg/mL
  • Organism Species MoreHomo sapiens (Human)
  • ApplicationsWB
    If the antibody is used in flow cytometry, please check FCM antibodies.
  • Downloadn/a
  • UOM 20µl100µl 200µl 1ml 10ml
  • FOB US$ 121  US$ 282  US$ 403  US$ 1008  US$ 4030 
    For more details, please contact local distributors!

SPECIFITY

The antibody is a mouse monoclonal antibody raised against OCLN. It has been selected for its ability to recognize OCLN in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.1-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Brain Research HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9 ScienceDirect: S0006899311021408
Plos one Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation PubMed: PMC3688973
Journal of Neurotrauma A new panel of blood biomarkers for the diagnosis of mild traumatic brain injury/concussion in adults PubMed: 25794137
United States Patent Application Methods for Diagnosis and Treatment of Concussion or Brain Injury 2016:0103140
Sci Rep.  Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke articles:srep40331
Frontiers in Pharmacology Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal … Pubmed:29375374
Thorax Fas activation alters tight junction proteins in acute lung injury Pubmed: 30385692
Antioxidants (Basel). The Effect of Dietary Quercetin on the Glutathione Redox System and Small Intestinal Functionality of Weaned Piglets Pubmed: 31426309
DISEASE MARKERS Peripheral blood occludin level as a biomarker for preoperative cerebral edema in patients with brain tumors Pubmed: 32884584
Burns Open Intestinal Permeability in Participants With Thermal Injury: A Case Series From a Prospective, Longitudinal Study (HESTIA)
PLoS One A comparison of the effects of monotherapy with rosuvastatin, atorvastatin or ezetimibe versus combination treatment with rosuvastatin-ezetimibe and … 34492054
CNS Neuroscience & Therapeutics Higher serum occludin after successful reperfusion Is associated with early neurological deterioration Pubmed:35338575
Impact de l'incorporation d'acides gras à chaine moyenne, de suppléments de levures et d'avoine nue sur la santé intestinale ainsi que sur la consommation …
Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
RPC228Ra01 Recombinant Occludin (OCLN) Positive Control; Immunogen; SDS-PAGE; WB.
PAC228Ra01 Polyclonal Antibody to Occludin (OCLN) WB; IHC; ICC; IP.
MAC228Ra21 Monoclonal Antibody to Occludin (OCLN) WB
MAC228Ra23 Monoclonal Antibody to Occludin (OCLN) WB
MAC228Ra24 Monoclonal Antibody to Occludin (OCLN) WB
MAC228Ra25 Monoclonal Antibody to Occludin (OCLN) WB
MAC228Ra26 Monoclonal Antibody to Occludin (OCLN) WB
MAC228Ra22 Monoclonal Antibody to Occludin (OCLN) WB
SEC228Ra ELISA Kit for Occludin (OCLN) Enzyme-linked immunosorbent assay for Antigen Detection.
LMC228Ra Multiplex Assay Kit for Occludin (OCLN) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.
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