Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A)

[Edit]

CD120A; P55; TBP1; FPF; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60; P55-R; P60; Tumor necrosis factor receptor 1; Tumor necrosis factor-binding protein 1

Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A)

Tumor necrosis factor receptor superfamily, member 1A is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-kB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called periodic fever syndrome. Impaired receptor clearance is thought to be a mechanism of the disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB499Hu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Positive Control; Immunogen; SDS-PAGE; WB.
RPB499Hu02 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Positive Control; Immunogen; SDS-PAGE; WB.
APB499Hu01 Active Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Cell culture; Activity Assays.
APB499Hu02 Active Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Cell culture; Activity Assays.
Antibodies PAB499Hu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) WB; IHC; ICC; IP.
MAB499Hu21 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) WB; IHC; ICC; IP.
PAB499Hu02 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) WB; IHC; ICC; IP.
Assay Kits SEB499Hu ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB499Mu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB499Mu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) WB; IHC; ICC; IP.
LAB499Mu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) WB; IHC; ICC.
Assay Kits SEB499Mu ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB499Ra01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Positive Control; Immunogen; SDS-PAGE; WB.
RPB499Ra02 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB499Ra01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) WB; IHC; ICC; IP.
PAB499Ra02 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) WB; IHC; ICC; IP.
LAB499Ra71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) WB; IHC; ICC.
Assay Kits SEB499Ra ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor."Cell 61:351-359(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and expression of a receptor for human tumor necrosis factor."Cell 61:361-370(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein."DNA Cell Biol. 9:705-715(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor."EMBO J. 9:3269-3278(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein."Proc. Natl. Acad. Sci. U.S.A. 87:7380-7384(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of the human TNF receptor 1 (p60) gene (TNFR1) and localization to chromosome 12p13."Genomics 13:219-224(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."BMC Genomics 10:518-518(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis."Nephron 66:386-390(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors."J. Biol. Chem. 265:1531-1536(1990) [PubMed] [Europe PMC] [Abstract]
  13. "Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis."J. Virol. 72:3691-3697(1998) [PubMed] [Europe PMC] [Abstract]
  14. "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation."EMBO J. 18:3044-3053(1999) [PubMed] [Europe PMC] [Abstract]
  15. "F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis."J. Biol. Chem. 274:32461-32468(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I."J. Exp. Med. 189:1707-1714(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains."Science 283:543-546(1999) [PubMed] [Europe PMC] [Abstract]
  18. "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway."J. Biol. Chem. 279:52106-52116(2004) [PubMed] [Europe PMC] [Abstract]
  19. "The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-alpha signaling."J. Virol. 85:13260-13270(2011) [PubMed] [Europe PMC] [Abstract]
  20. "TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis." Nature 488:508-511(2012) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation."Cell 73:431-445(1993) [PubMed] [Europe PMC] [Abstract]
  22. "Structures of the extracellular domain of the type I tumor necrosis factor receptor."Structure 4:1251-1262(1996) [PubMed] [Europe PMC] [Abstract]
  23. "Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes." Cell 97:133-144(1999) [PubMed] [Europe PMC] [Abstract]
  24. "A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family."Arthritis Rheum. 43:1535-1542(2000) [PubMed] [Europe PMC] [Abstract]
  25. "The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers."Am. J. Hum. Genet. 69:301-314(2001) [PubMed] [Europe PMC] [Abstract]
  26. "Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes." Arthritis Rheum. 48:2632-2644(2003) [PubMed] [Europe PMC] [Abstract]
  27. "Tumour necrosis factor receptor-associated periodic syndrome with a novel mutation in the TNFRSF1A gene in a Japanese family."Eur. J. Pediatr. 163:30-32(2004) [PubMed] [Europe PMC] [Abstract]