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Recombinant Beta-Site APP Cleaving Enzyme 1 (bACE1)

ASP2; Beta Secretase; Memapsin 2; Aspartyl protease 2; Beta-site amyloid precursor protein cleaving enzyme 1; Membrane-associated aspartic protease 2

  • Product No.RPA718Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationMembrane
  • Predicted Molecular Mass22.4kDa
  • Accurate Molecular Mass23kDa(Analysis of differences refer to the manual)
  • Residues & TagsGly181~Tyr366 (Accession # P56819) with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
  • Traits Freeze-dried powder
  • Purity> 97%
  • Isoelectric Point5.71
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 180  US$ 450  US$ 900  US$ 2700  US$ 6750 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Food & Function Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer’s disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice pubmed:29292421
Journal of Functional Foods EPA enriched ethanolamine plasmalogens significantly improve cognition of Alzheimer's disease mouse model by suppressing β-amyloid generation 10.1016/j.jff.2017.12.016
Journal of Nutritional Biochemistry Mechanisms of DHA-enriched phospholipids in improving cognitive deficits in aged SAMP8 mice with high-fat diet Pubmed:29986309
Neurotoxicology Involvement of hippocampal agmatine in β1-42 amyloid induced memory impairment, neuroinflammation and BDNF signaling disruption in mice Pubmed: 32522471
Food Chem Toxicol Effects of Alcohol Intake on Cognitive Function and ¦Â-amyloid Protein in APP/PS1 Transgenic Mice 33737111
Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
RPA718Ra01 Recombinant Beta-Site APP Cleaving Enzyme 1 (bACE1) Positive Control; Immunogen; SDS-PAGE; WB.
PAA718Ra01 Polyclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) WB; IHC; ICC; IP.
MAA718Ra21 Monoclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) WB; IHC; ICC; IP.
SEA718Ra ELISA Kit for Beta-Site APP Cleaving Enzyme 1 (bACE1) Enzyme-linked immunosorbent assay for Antigen Detection.
LMA718Ra Multiplex Assay Kit for Beta-Site APP Cleaving Enzyme 1 (bACE1) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.